The respective Serie A ambitions of AC Milan and Atalanta took a hit following a goalless draw at San Siro.
A single point means the Rossoneri are six shy of leaders Juventus, who could further increase their advantage in the Serie A title race with victory over second-placed Roma.
Atalanta, meanwhile, have steadied the ship after suffering back-to-back defeats that slowed their charge into the Europa League spots, but they will now fear losing ground to the likes of Fiorentina.
Levan Mchedlidze scored twice as Empoli pulled away from the drop zone with a 2-0 home win over Cagliari.
The Georgian striker had both of his goals laid on by Guido Marilungo, who picked out Mchedlidze in the Sardinians’ box in the eighth minute before finding his teammate again 18 minutes from time.
Empoli dominated from start to finish and Marilungo could have got on the scoresheet had he directed a right-footed shot on target just after the half-hour mark.
Cagliari had a late opportunity to halve the deficit but substitute Joao Pedro saw his penalty saved by Lukasz Skorupski.