Gonzalo Higuain scored the winner against his former club Napoli as Juventus extended their winning home run in Serie A to 22 matches.
Juve’s 2-1 win lifted them five points clear of closest rivals Roma at the top of the table, while it was Higuain’s first goal against Napoli since his move to Turin for £75 million in July.
Leonardo Bonucci had fired Juve into the lead early in the second half when he lashed home a spectacular volley after Napoli had made a hash of clearing a corner.
Napoli responded quickly and were level four minutes later when Jose Callejon caught the Juventus defence flat-footed to calmly slot the ball beneath Gianluigi Buffon, but Argentina international Higuain had the last word, firing home a rebound inside the area in the 82nd minute.
Juve’s last league defeat on home soil was on the opening day of the 2015-16 season when they lost 1-0 to Udinese.
In the day’s other clash, Nikola Kalinic’s first-half penalty secured Fiorentina a 1-0 win at 10-man Bologna and extended their unbeaten run to five games in all competitions.
Bologna were a man down for an hour after defender Daniele Gastaldello had been shown a straight red card for hauling down former Blackburn striker Kalinic, who picked himself up to place his 31st-minute spot-kick into the bottom corner.